Methodology for the synthesis of closed ecological systems based on the developed biotechnology of biosynthesis parametric control in populations of microorganisms and plants was developed. It allowed developing «Bios», the first functioning closed ecosystem for human life support remaining unique. Nowadays the research is going on in collaboration with the European Space Agency.
The experimental model of a new generation Bioregenerative life support systems (BLSS) for deep space missions, based on a new approach to the repeating of matter cycle — the biological and physico-chemical «burning» of dead-end vegetable products, which provided BLSS increased resistance and cycle degree of isolation more than 95 % has been calculated and created.
The developed methodology is transferred to the study of nature ecosystems.
Based on the received fundamental knowledge of the mechanisms controlling the synthesis of polymeric macromolecules by bacteria hemoautotrophic a family of bioresorbable linear biopolymers with different chemical structures was synthesized, their basic physical and chemical properties were studied. A family of polymeric medical devices was received from polyalcanoates. A complex biomedical research was carried out, specifications were developed and registered by the Russian State Standard for three types of polymers: for heart vessels prosthetics, for growing cells scaffolds, and for a long deposit of medicines within a body.
The genes and protein structure of emitting ferments — luciferases of several species of animals have been decoded. Based on these research of luminescent ferments and their genes by genetic engineering and chemical synthesis highly sensitive bioluminescent labels for molecular diagnostics (immune-ferment analysis, thyroid and gonadotropic hormones, alpha-fetoprotein, hepatitis B and reagents for the quantitative analysis of PCR products) have been created.